Papers Published in Scientific Journals
Research is essential for the advancement of any medical specialty and providing the best available care to patients. Research is carried out to develop and implement new and more effective treatments as well as audit and evaluate the results of the currently used treatments. Dr. Aditi Bhatt has been involved in research on the treatment of peritoneal cancer since the beginning of her journey in this field collaborating with surgeons and clinicians in India and around the world.
She has published two books on Peritoneal cancer.
– Management of Peritoneal Metastases- Cytoreductive surgery, HIPEC and beyond (https://link.springer.com/book/10.1007/978-981-10-7053-2)
– Pathology of Peritoneal Metastases- The Unchartered fields (https://link.springer.com/book/10.1007/978-981-15-3773-8)
- Bhatt A, Van der Speeten K, Hubner M, Kusamura S, Glehen O. Standardizing HIPEC Methodology and Regimens- A Prelude to the PSOGI Expert Consensus. Ann of Surg Oncol (2021) Article in press.
- Bhatt A, de Hingh I, Van der Speeten K, Hubner M, Deraco M, Bakrin N, Villeneuve L, Kusamura S, Glehen O. HIPEC Methodology and Regimens- The Need for an Expert Consensus. Ann of Surg Oncol (2021) Article in press.
- Bhatt A, Mehta S, Kammar P, Saklani A. Limitations of the PRODIGE 7 trial. Lancet Oncol. 2021 May;22(5):e175. doi: 10.1016/S1470-2045(21)00062-0. PMID: 33932373.
- Bhatt A, Sinukumar S, Parikh L, Mehta S, Shaikh S, Jumle N, Kammar P. Total parietal peritonectomy performed during interval cytoreductive surgery for advanced epithelial serous ovarian cancer results in a low incidence of platinum resistant recurrence- results of a prospective multi-centre study. Eur J Surg Oncol. 2021 Apr 14:S0748-7983(21)00408-X. doi: 10.1016/j.ejso.2021.04.003. Epub ahead of print. PMID: 33875284.
- Sinukumar S, Damodaran D, Ray M, Mehta S, Paul L, Bhatt A. Pattern of recurrence after interval cytoreductive surgery and HIPEC following neoadjuvant chemotherapy in primary advanced stage IIIC/IVA epithelial ovarian cancer. Eur J Surg Oncol. 2021 Jan 22:S0748-7983(21)00040-8. doi: 10.1016/j.ejso.2021.01.013. Epub ahead of print. PMID: 33509612.
- Bhatt A, Benzerdjeb N, Passot G, Kammar P, Mehta S, Laplace N, Cotte E, Glehen O. Implications of Pathologic Findings in Cytoreductive Surgery Specimens on Treatment of Colorectal Peritoneal Metastases: Results of a Prospective Multicentric Study. Dis Colon Rectum. 2021 May;64(5):534-544. doi: 10.1097/DCR.0000000000001904. PMID: 33496472.
- Bhatt A, Képénékian V, Benzerdjeb N, Glehen O. ASO Author Reflections: Potential Therapeutic Implications and Prediction of Pathological Complete Response to Systemic Chemotherapy in Colorectal Peritoneal Metastases. Ann Surg Oncol. 2020 Nov 19. doi: 10.1245/s10434-020- 09378-6. Epub ahead of print. PMID: 33211229. 5
- Bhatt A, Rousset P, Benzerdjeb N, Kammar P, Mehta S, Parikh L, Goswami G, Shaikh S, Kepenekian V, Passot G, Glehen O. Clinical and Radiologic Predictors of a Pathologic Complete Response to Neoadjuvant Chemotherapy (NACT) in Patients Undergoing Cytoreductive Surgery for Colorectal Peritoneal Metastases: Results of a Prospective Multi-center Study. Ann Surg Oncol. 2020 Nov 18. doi: 10.1245/s10434-020-09330-8. Epub ahead of print. PMID: 33210270.
- Bhatt A, Bakrin N, Kammar P, Mehta S, Sinukumar S, Parikh L, Shaikh S, Mishra S, Mallaya M, Kepenekian V, Benzerdjeb N, Glehen O. Distribution of residual disease in the peritoneum following neoadjuvant chemotherapy in advanced epithelial ovarian cancer and its potential therapeutic implications. Eur J Surg Oncol. 2021 Jan;47(1):181-187. doi: 10.1016/j.ejso.2020.10.012. Epub 2020 Oct 14. PMID: 33071172.
- Bhatt A, Rousset P, Benzerdjeb N, Kammar P, Mehta S, Parikh L, Goswami G, Shaikh S, Kepenekian V, Passot G, Glehen O. Prospective correlation of the radiological, surgical and pathological findings in patients undergoing cytoreductive surgery for colorectal peritoneal metastases: implications for the preoperative estimation of the peritoneal cancer index. Colorectal Dis. 2020 Sep 17. doi: 10.1111/codi.15368. Epub ahead of print. PMID: 32940414.
- Sgarbura O, Villeneuve L, Alyami M, Bakrin N, Torrent JJ, Eveno C, Hübner M; ISSPP PIPAC study group. Current practice of pressurized intraperitoneal aerosol chemotherapy (PIPAC): Still standardized or on the verge of diversification? Eur J Surg Oncol. 2021 Jan;47(1):149-156. doi: 10.1016/j.ejso.2020.08.020. Epub 2020 Aug 29. PMID: 32900609.
- Bhatt A, Kammar P, Sinukumar S, Parikh L, Jumle N, Shaikh S, Mehta S. Total Parietal Peritonectomy Can Be Performed with Acceptable Morbidity for Patients with Advanced Ovarian Cancer After Neoadjuvant Chemotherapy: Results From a Prospective Multi-centric Study. Ann Surg Oncol. 2021 Feb;28(2):1118-1129. doi: 10.1245/s10434-020-08918-4. Epub 2020 Aug 3. PMID: 32748154.
- Bhatt A, Kammar P, Mehta S, Sinukumar S. ASO Author Reflections: Total Parietal Peritonectomy During Interval Cytoreductive Surgery for Advanced Ovarian Cancer-Proof-ofPrinciple and Analysis of Morbidity. Ann Surg Oncol. 2020 Dec;27(Suppl 3):861-862. doi: 10.1245/s10434-020-08940-6. Epub 2020 Jul 27. PMID: 32720047.
- Bhatt A, Bakrin N, Gertych W, Kammar P, Parikh L, Sheth S, Shaikh S, DevouassouxShisheboran M, Glehen O. Extent and distribution of peritoneal disease in patients undergoing cytoreductive surgery for first platinum sensitive recurrence in ovarian cancer and its potential therapeutic implications. Eur J Surg Oncol. 2020 Dec;46(12):2276-2282. doi: 10.1016/j.ejso.2020.05.029. Epub 2020 Jun 24. PMID: 32600895.
- Bhatt A, Mishra S, Parikh L, Sheth S, Gorur I. Essentials for Pathological Evaluation of Peritoneal Surface Malignancies and Synoptic Reporting of Cytoreductive Surgery Specimens-A review and evidence-based guide. Indian J Surg Oncol. 2020 Mar;11(1):101-126. doi: 10.1007/s13193-019- 00897-7. Epub 2019 Mar 19. PMID: 32205979; PMCID: PMC7064688.
- Bhatt A, Glehen O. ASO Author Reflections: Tailoring the Extent of Peritoneal Resection for Peritoneal Metastases According to the Primary Tumor Site. Ann Surg Oncol. 2020 May;27(5):1471-1472. doi: 10.1245/s10434-020-08344-6. Epub 2020 Mar 11. PMID: 32162077.
- Bhatt A, Yonemura Y, Mehta S, Benzerdjeb N, Kammar P, Parikh L, Prabhu A, Mishra S, Shah M, Shaikh S, Kepenekian V, Bonnefoy I, Patel MD, Isaac S, Glehen O. The Pathologic Peritoneal Cancer Index (PCI) Strongly Differs From the Surgical PCI in Peritoneal Metastases Arising From Various Primary Tumors. Ann Surg Oncol. 2020 Aug;27(8):2985-2996. doi: 10.1245/s10434-020- 08234-x. Epub 2020 Feb 10. PMID: 32040698.
- Bhatt A, Glehen O. Extent of Peritoneal Resection for Peritoneal Metastases: Looking Beyond a Complete Cytoreduction. Ann Surg Oncol. 2020 May;27(5):1458-1470. doi: 10.1245/s10434-020- 08208-z. Epub 2020 Jan 21. PMID: 31965374. 6
- Bhatt A, Yonemura Y, Mehta S, Benzerdjeb N, Kammar P, Parikh L, Shah MY, Shaikh S, Prabhu A, Mishra S, Sinukumar S, Kepenekian V, Bakrin N, Passot G, Glehen O. Target region resection in patients undergoing cytoreductive surgery for peritoneal metastases-is it necessary in absence of visible disease? Eur J Surg Oncol. 2020 Apr;46(4 Pt A):582-589. doi: 10.1016/j.ejso.2019.11.495. Epub 2019 Nov 14. PMID: 31757660.
- Bhatt A, Yonemura Y, Benzerdjeb N, Mehta S, Mishra S, Parikh L, Kammar P, Shah MY, Prabhu A, Shaikh S, Patel MD, Isaac S, Glehen O. Pathological assessment of cytoreductive surgery specimens and its unexplored prognostic potential-a prospective multi-centric study. Eur J Surg Oncol. 2019 Dec;45(12):2398-2404. doi: 10.1016/j.ejso.2019.07.019. Epub 2019 Jul 16. PMID: 31337527.
- Goswami G, Kammar P, Mangal R, Shaikh S, Patel MD, Bhatt A. Accuracy of CT Scan in Predicting the Surgical PCI in Patients Undergoing Cytoreductive Surgery with/without HIPEC-a Prospective Single Institution Study. Indian J Surg Oncol. 2019 Jun;10(2):296-302. doi: 10.1007/s13193-019-00914-9. Epub 2019 Mar 28. PMID: 31168251; PMCID: PMC6527658.
- Lurvink RJ, Villeneuve L, Govaerts K, de Hingh IHJT, Moran BJ, Deraco M, Van der Speeten K, Glehen O, Kepenekian V, Kusamura S; List of PSOGI collaborators. The Delphi and GRADE methodology used in the PSOGI 2018 consensus statement on Pseudomyxoma Peritonei and Peritoneal Mesothelioma. Eur J Surg Oncol. 2021 Jan;47(1):4-10. doi: 10.1016/j.ejso.2019.03.012. Epub 2019 Mar
- PMID: 30954350. 23. Katdare N, Prabhu R, Mishra S, Mehta S, Bhatt A. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): Initial Experience from Indian Centers and a Review of Literature. Indian J Surg Oncol. 2019 Mar;10(1):24-30. doi: 10.1007/s13193-018-0771-5. Epub 2018 May 16. PMID: 30948867; PMCID: PMC6414563.
- Patel MD, Damodaran D, Rangole A, Shaikh S, Shah K, Bagwade R, Bhatt A. Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Malignancies-Experience from Indian Centers. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):91-98. doi: 10.1007/s13193-018-0859-y. Epub 2018 Dec 11. PMID: 30886500; PMCID: PMC6397125.
- Kammar P, Bhatt A, Anam J, Waghoo S, Pandey J, Mehta S. Correlation Between Pelvic Peritoneal Disease and Nodal Metastasis in Advanced Ovarian Cancer: Can Intraoperative Findings Define the Need for Systematic Nodal Dissection? Indian J Surg Oncol. 2019 Feb;10(Suppl 1):84-90. doi: 10.1007/s13193-019-00881-1. Epub 2019 Feb 7. PMID: 30886499; PMCID: PMC6397118.
- Sinukumar S, Mehta S, Damodaran D, Rajan F, Zaveri S, Ray M, Katdare N, Sethna K, Patel MD, Kammer P, Peedicayil A, Bhatt A. Failure-to-Rescue Following Cytoreductive Surgery with or Without HIPEC is Determined by the Type of Complication-a Retrospective Study by INDEPSO. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):71-79. doi: 10.1007/s13193-019-00877-x. Epub 2019 Jan 14. PMID: 30886497; PMCID: PMC6397122.
- Sinukumar S, Mehta S, As R, Damodaran D, Ray M, Zaveri S, Kammar P, Bhatt A. Analysis of Clinical Outcomes of Pseudomyxoma Peritonei from Appendicular Origin Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy-A Retrospective Study from INDEPSO. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):65-70. doi: 10.1007/s13193-018- 00870-w. Epub 2019 Jan 11. PMID: 30886496; PMCID: PMC6397130.
- Sinukumar S, Mehta S, As R, Damodaran D, Ray M, Zaveri S, Kammar P, Bhatt A. Analysis of Clinical Outcomes of Pseudomyxoma Peritonei from Appendicular Origin Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy-A Retrospective Study from INDEPSO. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):65-70. doi: 10.1007/s13193-018- 00870-w. Epub 2019 Jan 11. PMID: 30886496; PMCID: PMC6397130.
- Bhatt A, Sinukumar S, Rajan F, Damodaran D, Ray M, Zaveri S, Kammar P, Mehta S. Impact of Radicality Versus Timing of Surgery in Patients with Advanced Ovarian Cancer (Stage III C) 7 Undergoing CRS and HIPEC-a Retrospective Study by INDEPSO. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):57-64. doi: 10.1007/s13193-019-00875-z. Epub 2019 Jan 16. PMID: 30886495; PMCID: PMC6397116.
- Bhatt A, Kammar P, Mehta S, Damodaran D, Zaveri S, Patel MD, Sinukumar S, Ray M, Seshadri R. Chasing Rainbows? the Possibility of "Cure" in Patients with Colorectal Peritoneal Metastases Undergoing Cytoreductive Surgery and HIPEC-a Retrospective Study by INDEPSO. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):49-56. doi: 10.1007/s13193-019-00879-9. Epub 2019 Jan 30. PMID: 30886494; PMCID: PMC6397129.
- Bhatt A, Mehta S, Seshadri RA. The Current Status of Peritoneal Surface Oncology in India. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):41-48. doi: 10.1007/s13193-018-00871-9. Epub 2019 Jan 17. PMID: 30886493; PMCID: PMC6397124.
- Gopinath KS, Bhatt A. Preface 'Changing Trend in Peritoneal Surface Oncology in Asian Countries'. Indian J Surg Oncol. 2019 Feb;10(Suppl 1):1-2. doi: 10.1007/s13193-019-00895-9. Epub 2019 Feb 12. PMID: 30886485; PMCID: PMC6397128.
- Sinukumar S, Rajan F, Mehta S, Damodaran D, Zaveri S, Kammar P, Bhatt A. A comparison of outcomes following total and selective peritonectomy performed at the time of interval cytoreductive surgery for advanced serous epithelial ovarian, fallopian tube and primary peritoneal cancer - A study by INDEPSO. Eur J Surg Oncol. 2021 Jan;47(1):75-81. doi: 10.1016/j.ejso.2019.02.031. Epub 2019 Feb 23. PMID: 30857879.
- Bhatt A, Sinukumar S, Mehta S, Damodaran D, Zaveri S, Kammar P, Mishra S, Parikh L, Ranade R, Penumadu P, Rajan F. Patterns of pathological response to neoadjuvant chemotherapy and its clinical implications in patients undergoing interval cytoreductive surgery for advanced serous epithelial ovarian cancer- A study by the Indian Network for Development of Peritoneal Surface Oncology (INDEPSO). Eur J Surg Oncol. 2019 Apr;45(4):666-671. doi: 10.1016/j.ejso.2019.01.009. Epub 2019 Jan 9. PMID: 30661922.
- Bhatt A, Mehta SS, Zaveri S, Rajan F, Ray M, Sethna K, Katdare N, Patel MD, Kammar P, Prabhu R, Sinukumar S, Mishra S, Rangarajan B, Rangole A, Damodaran D, Penumadu P, Ganesh M, Peedicayil A, Raj H, Seshadri R. Treading the beaten path with old and new obstacles: a report from the Indian HIPEC registry. Int J Hyperthermia. 2018;35(1):361-369. doi: 10.1080/02656736.2018.1503345. Epub 2018 Oct 9. PMID: 30300029.
- Bhatt A1 , Mishra S2 , Prabhu R3 , Ramaswamy V2 , George A4 , Bhandare S5 , Shah M5 , Mehta S6 . Can low grade PMP be divided into prognostically distinct subgroups based on histological features? A retrospective study and the importance of using the appropriate classification. Eur J Surg Oncol. 2018 Apr 12. pii: S0748-7983(18)31002-3. doi: 10.1016/j.ejso.2018.03.032.
- Bhatt, A., Prabhu, R., Sethna, K., et al. (2017). The “homemade” HIPEC machine – a costeffective alternative in low-resource countries . Pleura and Peritoneum, 0(0), pp. -. Retrieved 3 Dec. 2017, from doi:10.1515/pp-2017-0022
- Bhatt, A., Mehta, S., Ramakrishnan AS et al. Setting up of the Indian HIPEC registry- a registry for Indian patients with peritoneal surface malignancies. Indian J Surg Oncol (2017) 8: 527. https://doi.org/10.1007/s13193-017-0693-7
- Bhatt A1 , Sheshadri D, Chandan G, Ramaswamy V, Pandey J, Bhorkar N, Agrawal D, Mehta S. Outcomes of cytoreductive surgery and HIPEC for pseudomyxoma peritonei of appendiceal origin from two Indian centers: A preliminary five-year experience. J BUON. 2017 Jan-Feb;22(1):251- 257.
- Bhatt A, George A, Mehta S. CRS and HIPEC for PMP-Use of the LC-CUSUM to Determine the Number of Procedures Required to Attain a Minimal Level of Proficiency in Delivering the 8 Combined Modality Treatment. Indian J Surg Oncol. 2017 Dec;8(4):533-539. doi:10.1007/s13193-017-0692-8. Epub 2017 Aug 12. PMID: 29203986; PMCID: PMC5705518.
- Bhatt A, Mittal S, Gopinath KS. Safety considerations for Health care Workers involved in Cytoreductive Surgery and Perioperative chemotherapy. Indian Journal of Surgical Oncology.2016;7(2):249-257. doi:10.1007/s13193-016-0503-7.
- Bhatt A, Glehen O. The role of Cytoreductive Surgery and Hyperthermic IntraperitonealChemotherapy (HIPEC) in Ovarian Cancer: A Review. Indian Journal of Surgical Oncology. 2016;7(2):188-197. doi:10.1007/s13193-016-0501-9.
- Bhatt A, Goéré D. Cytoreductive Surgery plus HIPEC for Peritoneal Metastases from Colorectal Cancer. Indian Journal of Surgical Oncology. 2016;7(2):177-187. doi:10.1007/s13193-016-0499-
- Bhatt A, Mehta S, Seshadri RA, et al. The Initial Indian Experience with Cytoreductive Surgery and HIPEC in the Treatment of Peritoneal Metastases. Indian Journal of Surgical Oncology. 2016;7(2):160-165. doi:10.1007/s13193-016-0500-x.
- Mehta SS, Bhatt A, Glehen O. Cytoreductive Surgery and Peritonectomy Procedures. Indian Journal of Surgical Oncology. 2016;7(2):139-151. doi:10.1007/s13193-016-0505-5.
- S. J. Valle, N. A. Alzahrani, W. Liauw, P. H. Sugarbaker, A. Bhatt, D. L. Morris Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Methodology, Drugs andBidirectional Chemotherapy. Indian J Surg Oncol. 2016 Jun; 7(2): 152–159. Published online 2016 Feb 5. doi: 10.1007/s13193-016-0498-0
- Rangole Ashvin , Bhatt Aditi, Jain Nikhilesh Preoperative Management of Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Indian journal of surgical oncology p1-7. Online first 22 June 2016
- Bhatt A, Rousset P, Baratti D, et alPatterns of peritoneal dissemination and response to systemic chemotherapy in common and rare peritoneal tumours treated by cytoreductive surgery: study protocol of a prospective, multicentre, observational studyBMJ Open 2021;11:e046819. doi: 10.1136/bmjopen-2020-046819
- Bhandoria, Geetu, Solanki, Sohan Lal, Bhavsar, Mrugank, Balakrishnan, Kalpana, Bapuji, Cherukuri, Bhorkar, Nitin, Bhandarkar, Prashant, Bhosale, Sameer, Divatia, Jigeeshu V., Ghosh, Anik, Mahajan, Vikas, Peedicayil, Abraham, Nath, Praveen, Sinukumar, Snita, Thambudorai, Robin, Seshadri, Ramakrishnan Ayloor and Bhatt, Aditi. "Enhanced recovery after surgery (ERAS) in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): a cross-sectional survey: " Pleura and Peritoneum, vol. , no. , 2021, pp. 000010151520210117. https://doi.org/10.1515/pp-2021-0117
- Aditi Bhatt, Praveen Kammar, Snita Sinukumar, Gaurav Goswami, Bikas Mishra, Mrugank Bhavsar, Sakina Shaikh, Sameer Bhosale, Deepesh Aggarwal, Nitin Bhorkar, Sanket Mehta. Perioperative outcomes in patients treated with total parietal peritonectomy and multi-visceral resections with or without HIPEC at different time points in the history of advanced ovarian cancer. European Journal of Gynaecological Oncology, 2021, 42(4): 711-720.