What is PIPAC?

PIPAC is a new method of giving chemotherapy to patients with advanced abdominal cancer, in which chemotherapy is given directly into the abdominal cavity.

Usually, the cancer directed therapy is administered intravenously (through the veins) as a drip. But this method of intraperitoneal chemotherapy is given directly into the abdominal cavity in patients who have cancer spread to the peritoneum, the lining of the abdominal cavity and its organs.

The Procedure

In PIPAC, a chemotherapy vapor is generated using a special device called ‘Capnopen’ and this procedure is performed through laparoscopy. In laparoscopic surgeries, the pressure in the abdominal cavity is raised and the combined effect of this increased pressure and vaporized chemotherapy increases the drug concentration in the cancerous tissue.

A very small dose of chemotherapy is used in this method, leading to lesser side effects. Recent studies have shown that this form of chemotherapy delivery can be as effective as intravenous chemotherapy.